- determination of cell specificity
     - efficacy compared to the current references
     - in vitro
study of antitumor effects (cell lines, primary cultures)
     - in vivo
study of antitumor activity (rodent)
     - ex vivo
study of anti-diabetic activity (islets of Langerhans assay, ...)
     - in vivo
study of new anti-diabetic drugs in rodent (Insulin, glycemia studies)

Study of action mechanism                        

     - therapeutic class                       
     - cell cycle 
     - anti-angiogenic effects 
     - anti-hormonal effects 
     - cytotoxicity 
     - hematotoxicity (human progenitors) 
     - clonogenic assay (human cell lines) 
     - apoptosis studies

 photo credit: D..Auvray - C.RIS Pharma - All rights reserved - copy prohibited